What is ALK Antibody?
Anaplastic lymphoma kinase (ALK) gene is responsible for a transmembrane-receptor Tyrosine Kinase (RTK) which has an amino acid count of 1620. It belongs to the insulin receptor superfamily, and is typically present in neuron cells. The ALK gene is located on the chromosome 2p23.2.
This antibody recognizes the human P80 protein that is recognized as a hybrid of anaplastic lymphoma-kinase (ALK) gene as well as the nucleophosmin (NPM) gene that is a result of the translocation, which is seen in a third of the large lymphomas. You can get more info about ALK tyrosine kinase receptor antibody online.
This rabbit monoclonal antibody could be used to determine the presence of p80 in these lymphomas. It could also be used to determine the newly identified subtype of B-cell lymphoma, that expresses complete ALK protein. The 2:5 chromosomal translocation is usually connected to anaplastic large cell lymphomas.
This translocation generates a fusion gene that consists of the ALK gene as well as the nucleophosmin gene. The 3' portion of ALK which is derived from chromosome 2 is joined with the 5' segment of NPM on chromosome 5. A recent study has revealed that the NPM-ALK fusion gene is cancer-causing.
The amino acid sequences that have been deduced indicate how ALK is a new receptor protein-tyrosine kinase with an alleged transmembrane domain as well as the extracellular component. The sequences are missing in the product of the NPM-ALK transforming gene.